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Int J Mol Sci. 2016 Oct 17;17(10). pii: E1729.

Regulatory Roles of MicroRNAs in Diabetes.

Feng J1, Xing W2,3, Xie L4,5.

Author information

1
Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China. fengjuansdu@126.com.
2
Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China. wlxing@tsinghua.edu.cn.
3
National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China. wlxing@tsinghua.edu.cn.
4
Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China. xielan@tsinghua.edu.cn.
5
National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China. xielan@tsinghua.edu.cn.

Abstract

MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus.

KEYWORDS:

circulating miRNAs; diabetes; insulin resistance; miRNAs; β-cell function

PMID:
27763497
PMCID:
PMC5085760
DOI:
10.3390/ijms17101729
[Indexed for MEDLINE]
Free PMC Article

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