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Ann Neurol. 2016 Dec;80(6):935-938. doi: 10.1002/ana.24801. Epub 2016 Nov 14.

Psychiatric disorders prior to amyotrophic lateral sclerosis.

Author information

1
Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital.
2
Oxford University Nuffield Department of Population Health, Old Road Campus, Oxford, United Kingdom.

Abstract

It is recognized that neuropsychiatric conditions are overrepresented in amyotrophic lateral sclerosis (ALS) patient kindreds and psychiatric symptoms may precede the onset of motor symptoms. Using a hospital record linkage database, hospitalization with a diagnosis of schizophrenia, bipolar disorder, depression, or anxiety was significantly associated with a first diagnosis of ALS within the following year. This is likely to specifically reflect the clinicopathological overlap of ALS with frontotemporal dementia. A diagnosis of depression was significantly associated with a first record of ALS ≥5 years later, in keeping with growing evidence for major depressive disorder as an early marker of cerebral neurodegeneration. Ann Neurol 2016;80:935-938.

PMID:
27761925
PMCID:
PMC5215396
DOI:
10.1002/ana.24801
[Indexed for MEDLINE]
Free PMC Article

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