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J Cutan Aesthet Surg. 2016 Jul-Sep;9(3):152-156.

Role of Adipose-derived Stem Cells in Fat Grafting and Reconstructive Surgery.

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Royal College of Physicians and Surgeons of Glasgow, Glasgow G2 5RJ, UK.
Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, China.
Department of Surgery, Monash University, Clayton, VIC, Australia.


Autologous fat grafting is commonly utilised to reconstruct soft tissue defects caused by ageing, trauma, chronic wounds and cancer resection. The benefits of fat grafting are minimal donor site morbidity and ease of availability through liposuction or lipectomy. Nonetheless, survival and longevity of fat grafts remain poor post-engraftment. Various methods to enhance fat graft survival are currently under investigation and its stem cell constituents are of particular interest. Cell-assisted lipotransfer refers to the addition of adipose-derived stem cell (ASC) rich component of stromal vascular fraction to lipoaspirate, the results of which have proven promising. This article aims to review the role of ASCs in fat grafting and reconstructive surgery.


Adipose-derived stem cell; liposuction; mesenchymal stem cell; reconstruction

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