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Am J Dermatopathol. 2017 Oct;39(10):760-763. doi: 10.1097/DAD.0000000000000737.

Loss of Conventional Melanocytic Markers in Malignant Melanoma and Lymph Node Metastasis; an Uncommon but Dangerous Pitfall.

Author information

1
*Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA; and †Department of Anatomic Pathology, VA Puget Sound Health Care System, Seattle, WA.

Abstract

Although malignant melanomas exhibit a wide range of immunophenotypes, concurrent loss of all 3 conventional melanocytic markers (S-100, Melan-A, and HMB-45) is relatively rare. We report a case of primary malignant melanoma with lymph node metastasis, both exhibiting loss of immunoreactivity for conventional melanocytic markers, while aberrantly expressing epithelial antigenicity (pancytokeratin, CAM 5.2).

PMID:
27759690
DOI:
10.1097/DAD.0000000000000737
[Indexed for MEDLINE]

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