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Br J Radiol. 2016 Dec;89(1068):20160421. Epub 2016 Oct 19.

Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: systematic review and meta-analysis.

Author information

1
1 Department of Radiology, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea.
2
2 Institute for Evidence-based Medicine, Cochrane Korea, Seoul, Republic of Korea.
3
3 Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.

Abstract

OBJECTIVE:

To compare the diagnostic accuracy of digital tomosynthesis (DTS) with that of chest radiography for the detection of pulmonary nodules by meta-analysis.

METHODS:

A systematic literature search was performed to identify relevant original studies from 1 January 1 1976 to 31 August 31 2016. The quality of included studies was assessed by quality assessment of diagnostic accuracy studies-2. Per-patient data were used to calculate the sensitivity and specificity and per-lesion data were used to calculate the detection rate. Summary receiver-operating characteristic curves were drawn for pulmonary nodule detection.

RESULTS:

16 studies met the inclusion criteria. 1017 patients on a per-patient basis and 2159 lesions on a per-lesion basis from 16 eligible studies were evaluated. The pooled patient-based sensitivity of DTS was 0.85 [95% confidence interval (CI) 0.83-0.88] and the specificity was 0.95 (0.93-0.96). The pooled sensitivity and specificity of chest radiography were 0.47 (0.44-0.51) and 0.37 (0.34-0.40), respectively. The per-lesion detection rate was 2.90 (95% CI 2.63-3.19).

CONCLUSION:

DTS has higher diagnostic accuracy than chest radiography for detection of pulmonary nodules. Chest radiography has low sensitivity but similar specificity, comparable with that of DTS. Advances in knowledge: DTS has higher diagnostic accuracy than chest radiography for the detection of pulmonary nodules.

PMID:
27759428
PMCID:
PMC5604914
DOI:
10.1259/bjr.20160421
[Indexed for MEDLINE]
Free PMC Article

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