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Org Lett. 2016 Nov 4;18(21):5740-5743. Epub 2016 Oct 19.

Synthesis of a Water-Soluble Carboxylatobiphen[4]arene and Its Selective Complexation toward Acetylcholine.

Ma J1, Meng Q2, Hu X3, Li B1,2, Ma S1, Hu B3, Li J1, Jia X1,4, Li C1.

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Department of Chemistry, Center for Supramolecular and Catalytic Chemistry, Shanghai University , Shanghai 200444, P. R. China.
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, P. R. China.
School of Physics and Materials Science, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University , Shanghai 200062, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.


The first water-soluble biphen[4]arene containing eight carboxylato moieties (carboxylatobiphen[4]arene, CBP4) has been synthesized. Selective molecular recognition of acetylcholine (ACh) against choline (Ch) and betaine (Bt) and pH-responsive host-guest complexation in aqueous media are described.

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