Format

Send to

Choose Destination
Sci Rep. 2016 Oct 19;6:35296. doi: 10.1038/srep35296.

ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy.

Author information

1
CPTP, INSERM U1043, CNRS UMR5282, Université Toulouse III, 31024 Toulouse, France.
2
Laboratoire de Virologie, IFB, CHU Toulouse, 31059 Toulouse, France.
3
Service de Gynécologie-Obstétrique, Clinique Sarrus-Teinturiers, 31300 Toulouse, France.
4
Service de Gynécologie-Obstétrique, CHU Toulouse, 31059 Toulouse, France.
5
IRD, UMR-Ministère de la Défense, Faculté de Pharmacie, Université de Montpellier, 34094 Montpellier, France.
6
INSERM UMRS976, Université Paris Diderot, Hôpital Saint-Louis, 75010 Paris, France.

Abstract

The outbreak of the Zika Virus (ZIKV) and its association with fetal abnormalities have raised worldwide concern. However, the cellular tropism and the mechanisms of ZIKV transmission to the fetus during early pregnancy are still largely unknown. Therefore, we ex vivo modeled the ZIKV transmission at the maternal-fetal interface using organ culture from first trimester pregnancy samples. Here, we provide evidence that ZIKV strain circulating in Brazil infects and damages tissue architecture of the maternal decidua basalis, the fetal placenta and umbilical cord. We also show that ZIKV replicates differentially in a wide range of maternal and fetal cells, including decidual fibroblasts and macrophages, trophoblasts, Hofbauer cells as well as umbilical cord mesenchymal stem cells. The striking cellular tropism of ZIKV and its cytopathic-induced tissue injury during the first trimester of pregnancy could provide an explanation for the irreversible congenital damages.

PMID:
27759009
PMCID:
PMC5069472
DOI:
10.1038/srep35296
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center