Immunoassay interference caused by heterophilic antibodies interacting with biotin

Clin Chem Lab Med. 2017 May 1;55(6):e122-e126. doi: 10.1515/cclm-2016-0786.

Authors

Michel J Vos¹, Jan M M Rondeel², G Sophie Mijnhout³, Erik Endert⁴

Affiliations

¹ Department of Laboratory Medicine, University Medical Center Groningen, PO box 30.001, 9700 RB Groningen, The.
² Department of Clinical Chemistry, Isala hospital, Zwolle, The.
³ Department of Internal Medicine, Isala hospital, Zwolle, The.
⁴ Laboratory of Endocrinology and Radiochemistry, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The.

PMID: 27754962
DOI: 10.1515/cclm-2016-0786

No abstract available

Keywords: biotin; heterophilic antibodies; immunoassay; interference.

Publication types

Letter

MeSH terms

Adult
Antibodies, Heterophile / chemistry
Antibodies, Heterophile / metabolism*
Antithyroid Agents / therapeutic use
Biomarkers / blood
Biotin / chemistry
Biotin / metabolism*
False Positive Reactions
Humans
Hyperthyroidism / drug therapy
Immunoassay / standards*
Male
Methimazole / therapeutic use
Thyrotropin / blood
Thyroxine / blood

Substances

Antibodies, Heterophile
Antithyroid Agents
Biomarkers
Methimazole
Biotin
Thyrotropin
Thyroxine