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J Endocrinol Invest. 2017 Mar;40(3):275-279. doi: 10.1007/s40618-016-0557-y. Epub 2016 Oct 17.

Effects of daily tadalafil on lower urinary tract symptoms in young men with multiple sclerosis and erectile dysfunction: a pilot study.

Author information

1
Department of Experimental Medicine, Endocrinology and Food and Science Section, Sapienza University of Rome, Rome, Italy.
2
Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
3
Department of Experimental Medicine, Endocrinology and Food and Science Section, Sapienza University of Rome, Rome, Italy. aversa@unicz.it.
4
Department of Experimental and Clinical Medicine, University Magna Graecia Catanzaro, Viale Europa - Germaneto, 88100, Catanzaro, Italy. aversa@unicz.it.

Abstract

PURPOSE:

Men affected by multiple sclerosis often experience neurogenic overactive bladder (OAB), lower urinary tract symptoms and erectile dysfunction (ED). The aim of the study was to investigate modifications of urinary and sexual functions after administration of daily tadalafil (TAD) 5 mg.

METHODS:

Twenty men were enrolled in a single-blind, 4-week prospective study while 10 men without treatment served as controls. Primary outcomes were changes from baseline of International Prostate Symptom (IPSS), OAB questionnaire (OAB-q-short form) and International Index of Erectile Function (IIEF-5) scores. To evaluate the influence of bladder filling on somatic reflexes, we studied variations of the H-reflex evoked by electrical stimuli applied to the tibial nerve at the popliteal fossa and recorded from the soleus muscle. Also testosterone/estradiol (T/E) ratio was measured before and after treatment.

RESULTS:

In TAD group, an improvement in IPSS (p < 0.001), OAB-q (p < 0.001) and IIEF-5 (p < 0.001) scores was found. Also, an increase in Q max (p < 0.01) and T/E ratio (p < 0.01) was found with a concomitant reduction in post-void residual volume (p < 0.001) without any changes in the H-reflex.

CONCLUSIONS:

The study demonstrates for the first time that daily TAD in patients with multiple sclerosis improves storage symptoms, post-void residual volume, steroid hormone pattern and ED without urodynamic changes.

KEYWORDS:

Estradiol; H-reflex; LUTS; Neurogenic bladder; Testosterone

PMID:
27752863
DOI:
10.1007/s40618-016-0557-y
[Indexed for MEDLINE]

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