Format

Send to

Choose Destination
Dalton Trans. 2016 Nov 28;45(44):17672-17680. Epub 2016 Oct 18.

Green synthesis of multimodal 'OFF-ON' activatable MRI/optical probes.

Author information

1
Advanced (Magnetic) Theranostic Nanostructures Group, INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal. juan.gallo@inl.int.

Abstract

Diagnosis by MRI is frequently non-trivial due to the low sensitivity of the technique. Signal enhancing contrast agents (CAs) are used to aid in the analysis of MR images. We present here a simple protocol for the preparation of responsive CAs based on Mn nanosheets. Mn nanostructures presented here undergo a chemical and structural change in the presence of altered physiological conditions that activate their signal. This strategy allows for a reduction of background, increasing the sensitivity of the technique. The simple synthetic protocol followed allows for the combination of the nanosheets with reporter molecules for other imaging techniques, like carbon quantum dots for optical imaging.

PMID:
27752669
DOI:
10.1039/c6dt02840c

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center