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J Affect Disord. 2017 Jan 15;208:56-61. doi: 10.1016/j.jad.2016.08.082. Epub 2016 Oct 11.

Vitamin D and depression.

Author information

1
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; Black Dog Institute, Sydney, NSW, Australia. Electronic address: g.parker@unsw.edu.au.
2
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; Black Dog Institute, Sydney, NSW, Australia.

Abstract

OBJECTIVE:

To examine whether vitamin D deficiency or insufficiency is associated with depression and whether vitamin D supplementation is an effective treatment for depression.

METHOD:

Empirical papers published in recent years were identified using three search engines and online databases - PubMed, Google Scholar and Cochrane Database. Specific search terms used were 'vitamin D', 'depression' and 'treatment' and articles were selected that examined the association between vitamin D deficiency/insufficiency and depression, vitamin D supplementation and Vitamin D as a treatment for depression. Our review weighted more recent studies (from 2011), although also considered earlier publications.

RESULTS:

Empirical studies appear to provide increasing evidence for an association between vitamin D insufficiency and depression, and for vitamin D supplementation and augmentation in those with clinical depression who are vitamin D deficient. Methodological limitations associated with many of the studies are detailed.

LIMITATIONS:

Articles were restricted to those in the English language while publication bias may have weighted studies with positive findings.

CONCLUSIONS:

There remains a need for empirical studies to move beyond cross-sectional designs to undertake more randomised controlled longitudinal trials so as to clarify the role of vitamin D in the pathogenesis of depression and its management, as well as to establish whether currently suggested associations are clinically significant and distinctive.

KEYWORDS:

Augmentation; Depression; Supplementation; Treatment; Vitamin D

PMID:
27750060
DOI:
10.1016/j.jad.2016.08.082
[Indexed for MEDLINE]

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