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Nat Neurosci. 2017 Jan;20(1):34-41. doi: 10.1038/nn.4416. Epub 2016 Oct 17.

TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.

Luo J1,2,3, Shen WL3, Montell C1,2.

Author information

1
Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, USA.
2
Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, USA.
3
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Avoidance of noxious ambient heat is crucial for survival. A well-known phenomenon is that animals are sensitive to the rate of temperature change. However, the cellular and molecular underpinnings through which animals sense and respond much more vigorously to fast temperature changes are unknown. Using Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and at higher frequencies when the temperature increased rapidly. We identified neurons in the brain that were sensitive to the speed of the temperature increase rather than just to the absolute temperature. These cellular and behavioral responses depended on the TRPA1 channel, whose activity responded to the rate of temperature increase. We propose that larvae use low-threshold sensors in the brain to monitor rapid temperature increases as a protective alert signal to trigger rolling behaviors, allowing fast escape before the temperature of the brain rises to dangerous levels.

PMID:
27749829
PMCID:
PMC5191986
DOI:
10.1038/nn.4416
[Indexed for MEDLINE]
Free PMC Article

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