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Nat Rev Immunol. 2017 Feb;17(2):97-111. doi: 10.1038/nri.2016.107. Epub 2016 Oct 17.

Immunogenic cell death in cancer and infectious disease.

Galluzzi L1,2,3,4,5,6, Buqué A2,3,4,5,6, Kepp O2,3,4,5,7, Zitvogel L6,8,9,10, Kroemer G2,3,4,5,7,11,12.

Author information

1
Department of Radiation Oncology, Weill Cornell Medical College, 10065 New York, New York, USA.
2
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.
3
INSERM, U1138, 75006 Paris, France.
4
Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.
5
Université Pierre et Marie Curie/Paris VI, 75006 Paris, France.
6
Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
7
Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
8
INSERM, U1015, 94805 Villejuif, France.
9
Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, 94805 Villejuif, France.
10
Université Paris Sud/Paris XI, 94270 Le Kremlin-Bicêtre, France.
11
Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, 17176 Stockholm, Sweden.
12
Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015 Paris, France.

Abstract

Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death. Several infectious pathogens have devised strategies to control cell death and limit the emission of danger signals from dying cells, thereby avoiding immune recognition. Similarly, cancer cells often escape immunosurveillance owing to defects in the molecular machinery that underlies the release of endogenous adjuvants. Here, we review current knowledge on the mechanisms that underlie the activation of immune responses against dying cells and their pathophysiological relevance.

PMID:
27748397
DOI:
10.1038/nri.2016.107
[Indexed for MEDLINE]

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