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J Dev Orig Health Dis. 2017 Feb;8(1):56-64. doi: 10.1017/S2040174416000568. Epub 2016 Oct 17.

Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: results from a randomized clinical trial.

Author information

1
1Kasiska School of Health Professions,Idaho State University,Pocatello,ID,USA.
2
2Department of International Health,Center for Human Nutrition,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.
3
4Instituto de Investigación Nutricional,Lima,Peru.
4
5Global Health Division,Becton Dickinson, Franklin Lakes,NJ,USA.
5
6Eunice Kennedy ShriverNational Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA.
6
3Department of Population, Family and Reproductive Health,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.

Abstract

Zinc is an essential micronutrient for the development of the fetal renal, cardiovascular and metabolic systems; however, there is limited evidence of its effects on the postnatal cardiometabolic function. In this study, we evaluated the effect of maternal zinc supplementation during pregnancy on the cardiometabolic profile of the offspring in childhood. A total of 242 pregnant women were randomly assigned to receive a daily supplement containing iron+folic acid with or without zinc. A follow-up study was conducted when children of participating mothers were 4.5 years of age to evaluate their cardiometabolic profile, including anthropometric measures of body size and composition, blood pressure, lipid profile and insulin resistance. No difference in measures of child cardiometabolic risk depending on whether mothers received supplemental zinc during pregnancy. Our results do not support the hypothesis that maternal zinc supplementation reduces the risk of offspring cardiometabolic disease.

KEYWORDS:

cardiovascular; metabolic; zinc

PMID:
27748235
PMCID:
PMC5822716
DOI:
10.1017/S2040174416000568
[Indexed for MEDLINE]
Free PMC Article

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