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Sports Med Open. 2015 Dec;1(1):6. Epub 2015 Mar 27.

ACTN3 R577X polymorphism is not associated with team sport athletic status in Italians.

Author information

1
Department of Life and Environmental Sciences, University of Cagliari, SS 554, km 4.500, Monserrato, 09042, Italy. myosotis.massidda@unica.it.
2
Department of Life and Environmental Sciences, University of Cagliari, SS 554, km 4.500, Monserrato, 09042, Italy.
3
FMSI CR Sardegna and Cagliari Calcio SpA, Viale Tiziano, Cagliari, 70-00196, Italy.
4
University of Cassino, Viale dell'Università, Cassino, 03043, Italy.

Abstract

BACKGROUND:

The ACTN3 gene may influence performance in team sports, in which sprint action and high-speed movements, regulated by the anaerobic energy system, are crucial to the ultimate success of a match. The aim of this study was to determine the association between the ACTN3 R577X (rs1815739) polymorphism and elite team sport athletic status in Italian male athletes.

METHODS:

We compared the genotype and allele frequency of the ACTN3 R577X polymorphism between team sport athletes (n = 75), endurance athletes (n = 40), sprint/power athletes (n = 64), and non-athletic healthy controls (n = 192) from Italy. Genomic DNA was collected using a buccal swab. Extraction was performed according to the manufacturer's directions provided with a commercially available kit (Qiagen S.r.l., Milan, Italy).

RESULTS:

Team sport athletes showed a lower frequency of the 577RR genotype compared to the 577XX genotype than sprint/power athletes (p = 0.044). However, the ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.

CONCLUSIONS:

Our results agree with a recent large-scale study involving athletes from Spain, Poland, and Russia. The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.

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