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J Ginseng Res. 2016 Oct;40(4):334-343. Epub 2015 Nov 2.

In vitro and in vivo evaluation of tissue-cultured mountain ginseng on penile erection.

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Department of Pharmacology, College of Medicine, Chung-ang University, Seoul, Korea.
Department of Anatomy, College of Medicine, Chung-ang University, Seoul, Korea.
Department of Physiology, College of Medicine, Chung-ang University, Seoul, Korea.
Department of Oriental Medical Food and Nutrition, Semyung University, Jecheon, Korea.
Omnica Co., Tokyo, Japan.



Progressed tissue culture techniques have allowed us to easily obtain mass products of tissue-cultured mountain ginseng over 100 yr old (TCMG-100). We investigated the effects of TCMG-100 extract on erectile function using in vitro and in vivo studies.


To examine the relaxation effects and mechanisms of action of TCMG-100 on rabbit cavernosal strips evaluated in an organ bath. To investigate the long-term treatment effect of TCMG-100, 8-wk administration was performed. After administration of TCMG-100, intracavernosal pressure, cyclic guanosine monophosphate and nitric oxide (NO) levels of cavernosal tissue, serum testosterone level, histological observation of collagen fiber, endothelium, smooth muscle cell, and transforming growth factor-β1 were investigated.


TCMG-100 extract displayed dose-dependent relaxation effects on precontracted rabbit corporal smooth muscle. The TCMG-100-induced relaxation was significantly reduced by removing the endothelium, and treatment with an NO synthase inhibitor or NO scavenger. Eight weeks of TCMG-100 administration increased intracavernosal pressure in a rat model. The levels of cyclic guanosine monophosphate and NO in the corpus callosum and serum testosterone level were also increased by TCMG-100 treatment. Furthermore, histological evaluation of collagen, smooth muscle, and endothelium showed increases in endothelium and smooth muscle, and a decrease in transforming growth factor-β1 expression.


These relaxation effects on corporal smooth muscle and increased erectile function suggest that TCMG-100 might be used as an alternative herbal medicine to improve erectile function.


corpus cavernosum; erectile function; mountain ginseng; nitric oxide; smooth muscle

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