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Neurobiol Learn Mem. 2016 Dec;136:183-188. doi: 10.1016/j.nlm.2016.10.005. Epub 2016 Oct 13.

Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice.

Author information

1
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
2
Division of Neurophysiology, MRC National Institute for Medical Research, London NW7 1AA, UK; MRC Centre for Developmental Neurobiology, King's College London, London WC2R 2LS, UK.
3
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK; Department of Neuroscience, Psychology & Behaviour, University of Leicester, Leicester LE1 7RH, UK. Electronic address: iea6@le.ac.uk.

Abstract

The hypothalamic hypocretin/orexin (HO) system holds a central role in the regulation of several physiological functions critical for food-seeking behavior including mnemonic processes for effective foraging behavior. It is unclear however whether physiological increases in HO neuronal activity can support such processes. Using a designer rM3Ds receptor activation approach increasing HO neuronal activity resulted in improved short-term memory for novel locations. When tested on a non-spatial novelty object recognition task no significant difference was detected between groups indicating that hypothalamic HO neuronal activation can selectively facilitate short-term spatial memory for potentially supporting memory for locations during active exploration.

KEYWORDS:

Hypothalamus; Orexin; Recognition memory; Spontaneous alternation

PMID:
27746379
PMCID:
PMC5139982
DOI:
10.1016/j.nlm.2016.10.005
[Indexed for MEDLINE]
Free PMC Article

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