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Schizophr Res. 2017 Jan;179:97-103. doi: 10.1016/j.schres.2016.09.035. Epub 2016 Oct 13.

The associations between multisensory temporal processing and symptoms of schizophrenia.

Author information

1
The University of Western Ontario, Department of Psychology, London, ON, Canada; The University of Western Ontario, Brain and Mind Institute, London, ON, Canada. Electronic address: Rsteve28@uwo.ca.
2
Vanderbilt University, Department of Psychology, Nashville, TN, USA.
3
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
4
University of Toronto, Department of Psychology, Toronto, ON, Canada; Rotman Research Institute, Toronto, ON, Canada.
5
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA; Vanderbilt University Medical Center, Department of Hearing and Speech Sciences, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University, Department of Psychology, Nashville, TN, USA; Vanderbilt University Medical Center, Department of Psychiatry, Nashville, TN, USA.

Abstract

Recent neurobiological accounts of schizophrenia have included an emphasis on changes in sensory processing. These sensory and perceptual deficits can have a cascading effect onto higher-level cognitive processes and clinical symptoms. One form of sensory dysfunction that has been consistently observed in schizophrenia is altered temporal processing. In this study, we investigated temporal processing within and across the auditory and visual modalities in individuals with schizophrenia (SCZ) and age-matched healthy controls. Individuals with SCZ showed auditory and visual temporal processing abnormalities, as well as multisensory temporal processing dysfunction that extended beyond that attributable to unisensory processing dysfunction. Most importantly, these multisensory temporal deficits were associated with the severity of hallucinations. This link between atypical multisensory temporal perception and clinical symptomatology suggests that clinical symptoms of schizophrenia may be at least partly a result of cascading effects from (multi)sensory disturbances. These results are discussed in terms of underlying neural bases and the possible implications for remediation.

KEYWORDS:

Audiovisual; Hallucinations; Multisensory integration; Schizophrenia; Speech perception; Temporal processing

PMID:
27746052
PMCID:
PMC5463449
DOI:
10.1016/j.schres.2016.09.035
[Indexed for MEDLINE]
Free PMC Article

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