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Mol Biol Evol. 2017 Jan;34(1):88-92. doi: 10.1093/molbev/msw222. Epub 2016 Oct 15.

Functional Effects of a Retained Ancestral Polymorphism in Prestin.

Li YY1,2, Liu Z3, Qi FY1, Zhou X1, Shi P3,4.

Author information

1
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
2
Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China.
3
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China zhenliu@mail.kiz.ac.cn ship@mail.kiz.ac.cn.
4
School of Future Technology, University of Chinese Academy of Sciences, Beijing, China.

Abstract

Molecular basis for mammalian echolocation has been receiving much concerns. Recent findings on the parallel evolution of prestin sequences among echolocating bats and toothed whales suggest that adaptations for high-frequency hearing have occurred during the evolution of echolocation. Here, we report that although the species tree for echolocating bats emitting echolocation calls with frequency modulated (FM) sweeps is paraphyletic, prestin exhibits similar functional changes between FM bats. Site-directed mutagenesis shows that the amino acid 308S in FM bats is responsible for the similar functional changes of prestin We strongly support that the occurrence of serine at position 308 is a case of hemiplasy, caused by incomplete lineage sorting of an ancestral polymorphism. Our study not only reveals sophisticated molecular basis of echolocation in bats, but also calls for caution in the inference of molecular convergence in species experiencing rapid radiation.

KEYWORDS:

SLC26A5; bat; echolocation; hemiplasy; homoplasy

PMID:
27744409
DOI:
10.1093/molbev/msw222
[Indexed for MEDLINE]

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