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Cytokine. 2017 Feb;90:14-20. doi: 10.1016/j.cyto.2016.09.021. Epub 2016 Oct 13.

Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy.

Author information

1
Palo Alto Medical Foundation Toxoplasma Serology Laboratory, Palo Alto, CA, USA; Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA; INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Toxines Microbiennes dans la Relation Hôte Pathogènes - Université de Nice Sophia Antipolis d, Faculté de Médecine, 06204 Nice Cedex 3, France; Parasitologie-Mycologie, Centre Hospitalier Universitaire l'Archet e, CS 23079, 06202 Nice Cedex 3, France. Electronic address: pomares.c@chu-nice.fr.
2
Stanford University Human Immune Monitoring Centre, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.
3
ESCP Europe, 75543 Paris Cedex 11, France.
4
Palo Alto Medical Foundation Toxoplasma Serology Laboratory, Palo Alto, CA, USA.
5
Department of Immunology, Fairchild Science Building, D033, 299 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5124, USA.
6
Palo Alto Medical Foundation Toxoplasma Serology Laboratory, Palo Alto, CA, USA; Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.

Abstract

INTRODUCTION:

Majority of Toxoplasma gondii infections are benign and asymptomatic; however, some patients experience toxoplasmic lymphadenitis (TL). Factors associated as to whether infection will be symptomatic or not are unknown.

METHODS:

Dye test titers of patients with acute toxoplasmosis (pregnant and not pregnant) with TL (TL+) were compared with those in patients with asymptomatic acute infection (TL-). Additionally, mean levels of 62 serum cytokines were compared between TL+ and TL- pregnant women and between TL+ pregnant and non-pregnant women.

RESULTS:

During acute infection, mean dye test titer was higher in TL+ than in TL- patients (p=0.021). In addition, out of 62 cytokines, CXCL9andCXCL10 levels were higher (p<0.05) and resistin mean levels were lower (p<0.05) in pregnant women with TL+ compared to TL-. Among patients with TL+, levels of VCAM1andCCL2 were lower (p<0.05) in pregnant women than in non-pregnant women.

CONCLUSION:

Here we report differences in dye test titers in patients with acute infection. Cytokine responses vary according to the presence of TL+ and to the pregnancy status. Factors underlying these differences are presently unknown and require further studies to define individual and combined roles of cytokines in TL+.

KEYWORDS:

Acute infection; Cytokine; Pregnancy; Serology; Toxoplasmic lymphadenitis

PMID:
27744174
DOI:
10.1016/j.cyto.2016.09.021
[Indexed for MEDLINE]

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