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Trends Cogn Sci. 2016 Dec;20(12):916-930. doi: 10.1016/j.tics.2016.09.007. Epub 2016 Oct 12.

Oscillatory Dynamics of Prefrontal Cognitive Control.

Author information

1
Helen Wills Neuroscience Institute, UC Berkeley, 132 Barker Hall, Berkeley, CA 94720, USA; Department of Psychology, University of Oslo, Forskningsveien 3A, 0373 Oslo, Norway; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Electronic address: rhelfrich@berkeley.edu.
2
Helen Wills Neuroscience Institute, UC Berkeley, 132 Barker Hall, Berkeley, CA 94720, USA; Department of Psychology, UC Berkeley, Tolman Hall, Berkeley, CA 94720, USA.

Abstract

The prefrontal cortex (PFC) provides the structural basis for numerous higher cognitive functions. However, it is still largely unknown which mechanisms provide the functional basis for flexible cognitive control of goal-directed behavior. Here, we review recent findings that suggest that the functional architecture of cognition is profoundly rhythmic and propose that the PFC serves as a conductor to orchestrate task-relevant large-scale networks. We highlight several studies that demonstrated that oscillatory dynamics, such as phase resetting, cross-frequency coupling (CFC), and entrainment, support PFC-dependent recruitment of task-relevant regions into coherent functional networks. Importantly, these findings support the notion that distinct spectral signatures reflect different cortical computations supporting effective multiplexing on different temporal channels along the same anatomical pathways.

KEYWORDS:

cross-frequency coupling; large-scale networks; network connectivity; neuronal entrainment; neuronal oscillations; prefrontal cortex

PMID:
27743685
PMCID:
PMC5127407
DOI:
10.1016/j.tics.2016.09.007
[Indexed for MEDLINE]
Free PMC Article

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