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  • PMID: 27742700 was deleted because it is a duplicate of PMID: 28172348
Bioinformatics. 2017 Feb 1;33(3):435-437. doi: 10.1093/bioinformatics/btw634.

ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.

Author information

1
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
2
RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
3
Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo/Fondazione MBBM, Monza, Italy.
4
Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
5
Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
6
Department of Hematology, Hopital Pitié-Salpêtrière and Pierre et Marie Curie University, Paris, France.
7
Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
8
Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Abstract

Motivation:

The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task.

Results:

We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations.

Availability and Implementation:

ARResT/Interrogate is implemented primarily in R, and is freely available at http://bat.infspire.org/arrest/interrogate/

Contact:

nikos.darzentas@gmail.com

Supplementary Information:

Supplementary data are available at Bioinformatics online.

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