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Dev Biol. 2017 Dec 1;432(1):34-42. doi: 10.1016/j.ydbio.2016.10.008. Epub 2016 Oct 11.

The dorsal spinal cord and hindbrain: From developmental mechanisms to functional circuits.

Author information

1
Max-Delbrück-Center for Molecular Medicine in the Helmholtz-Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany. Electronic address: luis.hernandes@mdc-berlin.de.
2
Max-Delbrück-Center for Molecular Medicine in the Helmholtz-Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
3
Max-Delbrück-Center for Molecular Medicine in the Helmholtz-Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany. Electronic address: cbirch@mdc-berlin.de.

Abstract

Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and relaying sensory perception and participate in the coordination of sensory-motor output. Numerous cellular and molecular mechanisms that underlie neuronal development in both regions of the nervous system are shared. We discuss here the mechanisms that generate neuronal diversity in the dorsal spinal cord and hindbrain, and emphasize similarities in patterning and neuronal specification. Insight into the developmental mechanisms has provided tools that can help to assign functions to small subpopulations of neurons. Hence, novel information on how mechanosensory or pain sensation is encoded under normal and neuropathic conditions has already emerged. Such studies show that the complex neuronal circuits that control perception of somatosensory and viscerosensory stimuli are becoming amenable to investigations.

PMID:
27742210
DOI:
10.1016/j.ydbio.2016.10.008
[Indexed for MEDLINE]
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