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Magn Reson Imaging Clin N Am. 2016 Nov;24(4):649-670. doi: 10.1016/j.mric.2016.06.005. Epub 2016 Sep 14.

Dynamic Susceptibility Contrast MR Imaging in Glioma: Review of Current Clinical Practice.

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Department of Diagnostic Imaging, Rhode Island Hospital, Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA. Electronic address:
Department of Radiology, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Lower Level Imaging L1600, Los Angeles, CA 90033, USA.
UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, Center for Computer Vision and Imaging Biomarkers, David Geffen School of Medicine at UCLA, 924 Westwood Boulevard, Suite 615, Los Angeles, CA 90024, USA.
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, 1621 East, Los Angeles, CA 90095, USA.


Dynamic susceptibility contrast (DSC) MR imaging, a perfusion-weighted MR imaging technique typically used in neuro-oncologic applications for estimating the relative cerebral blood volume within brain tumors, has demonstrated much potential for determining prognosis, predicting therapeutic response, and assessing early treatment response of gliomas. This review highlights recent developments using DSC-MR imaging and emphasizes the need for technical standardization and validation in prospective studies in order for this technique to become incorporated into standard-of-care imaging for patients with brain tumors.


Cerebral blood volume (CBV); Dynamic susceptibility contrast MR imaging (DSC-MR imaging); Glioblastoma; High-grade glioma; Prognosis; Pseudoprogression; Pseudoresponse; Response assessment

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