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Langmuir. 2016 Nov 15;32(45):11845-11853. Epub 2016 Nov 1.

Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems.

Author information

1
Department of Chemistry, University of Bath , Claverton Down, Bath BA2 7AY, United Kingdom.
2
Diamond Light Source, Harwell Science and Innovation Campus , Didcot, OX11 ODE, United Kingdom.
3
School of Science and Engineering, University of Dundee , Dundee, DD1 4HN, United Kingdom.
4
ISIS Spallation Neutron Source, STFC, Harwell Science and Innovation Campus, Didcot, OX11 OQX, United Kingdom.

Abstract

Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such "nanodiscs" and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.

PMID:
27739678
DOI:
10.1021/acs.langmuir.6b02927
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