Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast

Small. 2017 Jan;13(1):10.1002/smll.201602505. doi: 10.1002/smll.201602505. Epub 2016 Oct 14.

Abstract

Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.

Keywords: MD simulations; bilayers; contrast agents; porphyrin-phospholipid; water permeation.

MeSH terms

  • Contrast Media / chemistry*
  • Lipid Bilayers / chemistry*
  • Liposomes / chemistry
  • Magnetic Resonance Spectroscopy*
  • Molecular Dynamics Simulation
  • Phospholipids / chemistry*
  • Porphyrins / chemistry*
  • Water / chemistry*

Substances

  • Contrast Media
  • Lipid Bilayers
  • Liposomes
  • Phospholipids
  • Porphyrins
  • Water