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J Labelled Comp Radiopharm. 2016 Nov;59(13):576-581. doi: 10.1002/jlcr.3467. Epub 2016 Oct 13.

High specific activity is not optimal: 18 F-fluoroestradio positron emission tomography-computed tomography results in a breast cancer xenograft.

Yang Z1,2,3,4, Yuan H1,2,3,4, Xu X1,2,3,4, Gu B1,2,3,4, Wang M1,2,3,4, Zhang J1,2,3,4, Zhang Y1,2,3,4, Zhang Y1,2,3,4.

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Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Center for Biomedical Imaging, Fudan University, Shanghai, China.
Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, China.


The purpose of the preliminary study was to investigate whether high specific activity (SA) of 18 F-fluoroestradiol was optimal in breast cancer diagnosis. Imaging at variable SA was conducted in a ZR-75-1 xenograft model of estrogen-receptor positive human breast cancer in 6 mice. The region of interest was manually drawn, and the percent of injected dose per gram of the tumor and muscle in the regions of interest were recorded. Tumor-to-muscle ratio (T/M) was calculated and compared in each group with different SAs. In addition, the correlation between blood estradiol and sex hormone-binding globulin and the value of T/M were also analyzed. The value of T/M increased initially with the rise of SA and it reached the peak at SA of 1.6 Ci/μmol. After that, the value fell down sharply and remained stable from SA of 3.1 Ci/μmol. The value of T/M was highest at SA of 1.6 Ci/μmol (P < .001). Additionally, the blood levels of estradiol and sex hormone-binding globulin showed no correlation with the value of T/M (P > .05). High SA of 18 F-fluoroestradiol leads to low T/M results in breast cancer xenograft models. We should control SA in a reasonable range to obtain high-quality images.


18F-FES micro-PET/CT; breast cancer; nude mouse; specific activity

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