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Adv Exp Med Biol. 2016;936:11-29.

Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach.

Author information

1
Mathematical Oncology Laboratory (MôLAB), University of Castilla-La Mancha, Castilla-La Mancha, Spain.
2
Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.
3
Mathematical Oncology Laboratory (MôLAB), University of Castilla-La Mancha, Castilla-La Mancha, Spain. victor.perezgarcia@uclm.es.

Abstract

This chapter explores the use of mathematical models as promising and powerful tools to understand the complexity of tumors and their, frequently, hypoxic environment. We focus on gliomas, which are primary brain tumors derived from glial cells, mainly astrocytes and/or oligodendrocytes. A variety of mathematical models, based on ordinary and/or partial differential equations, have been developed both at the micro and macroscopic levels. The aim here is to describe in a quantitative way key physiopathological mechanisms relevant in these types of malignancies and to suggest optimal therapeutical strategies. More specifically, we consider novel therapies targeting thromboembolic phenomena to decrease cell invasion in high grade glioma or to delay the malignant transformation in low grade gliomas. This study has been the basis of a multidisciplinary collaboration involving, among others, neuro-oncologists, radiation oncologists, pathologists, cancer biologists, surgeons and mathematicians.

KEYWORDS:

Antithrombotics and cancer; Malignant transformation of low-grade gliomas; Mathematical models of hypoxia in tumors; Microscopic mathematical model of glioblastoma

PMID:
27739041
DOI:
10.1007/978-3-319-42023-3_2
[Indexed for MEDLINE]

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