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Ann Behav Med. 2017 Apr;51(2):251-260. doi: 10.1007/s12160-016-9848-y.

Obesity, Apolipoprotein E ε4, and Difficulties in Activities of Daily Living Among Older Adults: a 6-Year Follow-up Study.

Author information

1
Department of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan.
2
Department of Epidemiology and Public Health, University College London, London, UK.
3
Department of Epidemiology and Public Health, University College London, London, UK. powen.ku@gmail.com.
4
Graduate Institute of Sports and Health, National Changhua University of Education, No.1, Jinde Rd, Changhua City, 500, Taiwan. powen.ku@gmail.com.

Abstract

BACKGROUND:

Obesity has been associated with increased physical limitations among older adults, although few studies have adjusted for important covariates. There is limited information about the relationship between apolipoprotein E (APOE) polymorphisms and physical limitations, and the findings have been inconsistent.

PURPOSE:

This study examined the longitudinal associations of obesity and APOE ε4 with difficulties in activities of daily living (ADLs) over a 6-year follow-up period controlling for multiple covariates.

METHODS:

Data were analyzed from the Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan collected in 2000 and 2006, involving a cohort of 639 participants (mean age = 66). Body mass index (BMI) was used to define obesity at a baseline, and the APOE genotype was classified into an APOE ε4 carrier and non-carrier status. The combination of basic and instrumental activities of daily living (ADLs and IADLs) was used to define impaired ADLs.

RESULTS:

APOE ε4 carriers had greater difficulties in combined ADLs (incident rate ratio; IRR = 1.87, 95 % CI = 1.40-2.51) than non-carriers. Obese but not overweight adults had greater difficulties in activities of daily living (IRR = 1.59, 95 % CI = 1.20-2.10) compared with the normal/underweight group. Obese older adults without APOE ε4 had greater subsequent difficulties in ADLs than non-obese non-carriers. Among APOE ε4 carriers, obesity was not a significant risk factor for the development of impaired ADLs in older adults, indicating an interaction between genotype and obesity.

CONCLUSIONS:

The interaction between genotype and obesity phenotype adds new information about the determinants of physical impairment.

KEYWORDS:

Mobility; Overweight; Physical disability; Physical function; Weight status

PMID:
27738971
DOI:
10.1007/s12160-016-9848-y
[Indexed for MEDLINE]

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