Format

Send to

Choose Destination
Science. 2016 Oct 14;354(6309):197-202.

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.

Author information

1
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
2
Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.
3
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Division of Pathology, The Yerkes National Primate Center of Emory University, Atlanta, GA 30329, USA.
4
Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA 30322, USA.
5
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.
6
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30680, USA.
7
Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa.
8
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
9
Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.
10
Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD 21201, USA.
11
Division of Pathology, The Yerkes National Primate Center of Emory University, Atlanta, GA 30329, USA.
12
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. pathaaa@emory.edu.

Abstract

Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α4β7 integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4+ T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.

PMID:
27738167
PMCID:
PMC5405455
DOI:
10.1126/science.aag1276
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center