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J Eur Acad Dermatol Venereol. 2016 Dec;30(12):2038-2047. doi: 10.1111/jdv.13965. Epub 2016 Oct 13.

Microbiome in healthy skin, update for dermatologists.

Author information

1
Department of Dermato-cancerology, Nantes University, Nantes, France.
2
Department of Dermatology, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
3
San Gallicano Dermatological Institute, Rome, Italy.
4
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
5
Institute for Dermatology, Skin Health, Aging and Cancer, Madrid, Spain.
6
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
7
L'Oréal Research and Innovation, Tours, France.
8
Department of Dermatology and Allergy, University Medical Center, Bonn, Germany.

Abstract

The skin is a complex barrier organ made of a symbiotic relationship between microbial communities and host tissue via complex signals provided by the innate and the adaptive immune systems. It is constantly exposed to various endogenous and exogenous factors which impact this balanced system potentially leading to inflammatory skin conditions comprising infections, allergies or autoimmune diseases. Unlike the gut and stool microbiome which has been studied and described for many years, investigations on the skin or scalp microbiome only started recently. Researchers in microbiology and dermatology started using modern methods such as pyrosequencing assays of bacterial 16S rRNA genes to identify and characterize the different microorganisms present on the skin, to evaluate the bacterial diversity and their relative abundance and to understand how microbial diversity may contribute to skin health and dermatological conditions. This article aims to provide an overview on the knowledge about the skin microbiota, the microbiome and their importance in dermatology.

PMID:
27735094
PMCID:
PMC6084363
DOI:
10.1111/jdv.13965
[Indexed for MEDLINE]
Free PMC Article

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