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Clin Exp Dermatol. 2017 Jan;42(1):21-29. doi: 10.1111/ced.12950. Epub 2016 Oct 13.

Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde.

Author information

1
Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.

Abstract

BACKGROUND:

There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA).

AIM:

To clarify the association between vitiligo and SOD or MDA.

METHODS:

Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI.

RESULTS:

Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls.

CONCLUSIONS:

This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.

PMID:
27735067
DOI:
10.1111/ced.12950
[Indexed for MEDLINE]

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