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Med Biol Eng Comput. 2017 Aug;55(8):1163-1175. doi: 10.1007/s11517-016-1580-z. Epub 2016 Oct 12.

Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients.

Author information

1
Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy. filippo.molinari@polito.it.
2
Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy.
3
"Un Passo Insieme" ONLUS Foundation, Valdellatorre, Turin, Italy.
4
Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Clementi, 599489, Singapore.
5
Department of Biomedical Engineering, SIM University, Clementi, Singapore.
6
Scientific Society of Oxygen Ozone Therapy (SIOOT), Gorle, BG, Italy.
7
Geriatric and Emergency Medicine, Postgraduate School in Emergency Medicine, University of Pavia, Pavia, Italy.
8
Geriatric Division, ASP - IDR S. Margherita, Pavia, Italy.
9
Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy.
10
"Kaos" ONLUS Foundation, Turin, Italy.

Abstract

Ozone major autohemotherapy is effective in reducing the symptoms of multiple sclerosis (MS) patients, but its effects on brain are still not clear. In this work, we have monitored the changes in the cerebrovascular pattern of MS patients and normal subjects during major ozone autohemotherapy by using near-infrared spectroscopy (NIRS) as functional and vascular technique. NIRS signals are analyzed using a combination of time, time-frequency analysis and nonlinear analysis of intrinsic mode function signals obtained from empirical mode decomposition technique. Our results show that there is an improvement in the cerebrovascular pattern of all subjects indicated by increasing the entropy of the NIRS signals. Hence, we can conclude that the ozone therapy increases the brain metabolism and helps to recover from the lower activity levels which is predominant in MS patients.

KEYWORDS:

Cerebrovascular pattern; Empirical mode decomposition; Entropy; MANOVA; Multiple sclerosis; Near-infrared spectroscopy; Ozone autohemotherapy; Time–frequency

PMID:
27734309
DOI:
10.1007/s11517-016-1580-z
[Indexed for MEDLINE]

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