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J Antimicrob Chemother. 2017 Jan;72(1):95-98. Epub 2016 Oct 12.

Emergence of meningococci with reduced susceptibility to third-generation cephalosporins.

Author information

1
Institut Pasteur, Invasive Bacterial Infection and National Reference Centre for Meningococci, Paris, France.
2
Institut Pasteur, Invasive Bacterial Infection and National Reference Centre for Meningococci, Paris, France mktaha@pasteur.fr.

Abstract

OBJECTIVES:

Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012.

METHODS:

Invasive meningococcal isolates were typed by MLST and penA sequencing and their antibiotic susceptibility was tested.

RESULTS:

Isolates with reduced susceptibility to C3Gs represented 2% of all invasive isolates from 2012-15, but were absent before. They harboured a new penA allele, penA327, that was also detected in isolates from urethritis cases and in gonococci.

CONCLUSIONS:

Surveillance of these isolates should be enhanced as they may jeopardize the use of C3Gs in the management of invasive meningococcal disease.

PMID:
27733517
DOI:
10.1093/jac/dkw400
[Indexed for MEDLINE]

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