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Ther Deliv. 2016 Nov;7(11):751-760. Epub 2016 Oct 13.

Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper.

Author information

1
Department of Ophthalmology, University of California at San Francisco, 707 Oregon Ave, San Mateo, CA 94402, USA.
2
CODET Vision Institute, Tijuana, Mexico.
3
Department of Ophthalmology, University of Colorado, Aurora, CO, USA.
4
Mark Packer MD Consulting, Boulder, CO, USA.
5
Massachusetts Eye & Harvard University, Cambridge, MA, USA.
6
Department of Ophthalmology, Hamilton Glaucoma Center & Shiley Eye Institute, University of California at San Diego, CA, USA.

Abstract

AIM:

Eyedroppers deliver medication volumes exceeding conjunctival absorptive capacity, causing spillage and risking ocular/systemic complications. We evaluated piezoelectric microdosing. Results/methodology: Subjects (n = 102) received precision microdroplet delivery of phenylephrine (2.5%) and tropicamide (1.0%): 1 × 1.5 μl, 1 × 6 μl or 2 × 3 μl of each (randomized 1:1:1), into one eye. Contralateral eyes received eyedropper doses of both drugs. Outcomes were pupil dilation (0-60 min) and patient satisfaction. Six-microliter microdosing achieved comparable, and 2 × 3 μl met/exceeded dilation speed and magnitude versus eyedropper. Separately, participants preferred piezoelectric saline self-delivery to eyedroppers, reporting better head-positioning comfort, reduced tearing/overflow and increased likelihood of adhering to ocular medication regimens.

CONCLUSION:

Piezoelectric microdosing achieves comparable effects as eyedroppers delivering 4-17-fold larger doses. Microdosing may enhance patient adherence to ocular medication regimens while minimizing side effects.

KEYWORDS:

microdroplet ejection system; mydriasis; ocular drug delivery; ocular medication; piezoelectric; precision eye dosing

PMID:
27733098
DOI:
10.4155/tde-2016-0061
[Indexed for MEDLINE]

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