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J Infect Dis. 2016 Nov 1;214(9):1302-1308. Epub 2016 May 24.

No Evidence That HIV-1 Subtype C Infection Compromises the Efficacy of Tenofovir-Containing Regimens: Cohort Study in the United Kingdom.

Author information

1
MRC Clinical Trials Unit at UCL.
2
Public Health England, Birmingham Heartlands Hospital.
3
Brighton and Sussex Hospitals NHS Trust, United Kingdom.
4
HIV i-Base.
5
Health Service Laboratories, Royal Free Hospital, London.
6
Department of Infection and Population Health.
7
Division of Infection and Immunity, University College London.
8
Africa Centre for Population Health, University of KwaZulu-Natal, Durban, South Africa.

Abstract

Concern has been expressed that tenofovir-containing regimens may have reduced effectiveness in the treatment of human immunodeficiency virus type 1 (HIV-1) subtype C infections because of a propensity for these viruses to develop a key tenofovir-associated resistance mutation. We evaluated whether subtype influenced rates of virological failure in a cohort of 8746 patients from the United Kingdom who received a standard tenofovir-containing first-line regimen and were followed for a median of 3.3 years. In unadjusted analyses, the rate of failure was approximately 2-fold higher among patients infected with subtype C virus as compared to those with subtype B virus (hazard ratio [HR], 1.86; 95% confidence interval [CI], 1.50-2.31; P < .001). However, the increased risk was greatly attenuated in analyses adjusting for demographic and clinical factors (adjusted HR, 1.14; 95% CI, .83-1.58; P = .41). There were no differences between subtypes C and subtypes non-B and non-C in either univariate or multivariate analysis. These observations imply there is no intrinsic effect of viral subtype on the efficacy of tenofovir-containing regimens.

KEYWORDS:

HIV-1; K65R; subtype; tenofovir; virological failure

PMID:
27732929
PMCID:
PMC5079361
DOI:
10.1093/infdis/jiw213
[Indexed for MEDLINE]
Free PMC Article

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