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Anal Chem. 2016 Nov 15;88(22):10775-10784. Epub 2016 Oct 24.

Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.

Author information

1
UCSD Collaborative Mass Spectrometry Innovation Center, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
2
UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
3
Structural and Computational Biology, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, German y.
4
SCiLS GmbH , Fahrenheitstrasse 1, 28359 Bremen, Germany.
5
UCSD Department of Computer Science, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
6
Scripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
7
TU Berlin , Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.
8
UCSD Mathematics Undergraduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
9
Facultad de Medicina de la Universidad Autónoma de Madrid . Calle del Arzobispo Morcillo 4. 28029 Madrid, Spain.
10
UCSD Neurosciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
11
UCSD Biological Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
12
UCSD Chemistry and Biochemistry, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
13
UCSD Department of Pediatrics, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
14
UCSD Center for Microbiome Innovation, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
15
State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University , 130 West Changjiang Road Hefei 230036, P. R. China.
16
UCSD Biomedical Sciences Graduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
17
UCSD Department of Pharmacology, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
18
UCSD Department of Pathology, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
19
UCSD School of Medicine, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
20
UCSD Bioengineering Undergraduate Program, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.

Abstract

The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.

PMID:
27732780
PMCID:
PMC6326777
DOI:
10.1021/acs.analchem.6b03456
[Indexed for MEDLINE]
Free PMC Article

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