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FASEB J. 2017 Jan;31(1):203-211. doi: 10.1096/fj.201600263RR. Epub 2016 Oct 11.

Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.

Author information

1
Institut National de la Recherche Agronomique, Unités Mixtes de Recherche 1260, Marseille, France.
2
INSERM, Unités Mixtes de Recherche 1062, Nutrition, Obésité et Risque Thrombotique, Marseille, France.
3
Aix-Marseille Université, Faculté de Médecine, Marseille, France.
4
Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
5
MTA-DE Public Health Research Group, Hungarian Academy of Sciences, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
6
Unités Mixtes de Recherche, Institut National de la Recherche Agronomique (INRA) 1019 Unité de Nutrition Humaine, Centre de Recherches INRA de Clermont-Ferrand/Theix, Saint-Genès-Champanelle, France.
7
Departamento de Química Orgánica, Universidade de Vigo, Facultad de Química, Centro de Investigaciones Biomédicas and Instituto de Investigación Biomédica de Vigo, Vigo, Spain; and.
8
Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary; ralphruehl@web.de.
9
Paprika Bioanalytics BT, Debrecen, Hungary.

Abstract

Adiponectin is an adipocyte-derived adipokine with potent antidiabetic, anti-inflammatory, and antiatherogenic activity. Long-term, high-fat diet results in gain of body weight, adiposity, further inflammatory-based cardiovascular diseases, and reduced adiponectin secretion. Vitamin A derivatives/retinoids are involved in several of these processes, which mainly take place in white adipose tissue (WAT). In this study, we examined adiponectin expression as a function of dietary high-fat and high-vitamin A conditions in mice. A decrease of adiponectin expression in addition to an up-regulation of aldehyde dehydrogenase A1 (ALDH1A1), retinoid signaling, and retinoic acid response element signaling was selectively observed in WAT of mice fed a normal-vitamin A, high-fat diet. Reduced adiponectin expression in WAT was also observed in mice fed a high-vitamin A diet. Adipocyte cell culture revealed that endogenous and synthetic retinoic acid receptor (RAR)α- and RARγ-selective agonists, as well as a synthetic retinoid X receptor agonist, efficiently reduced adiponectin expression, whereas ALDH1A1 expression only increased with RAR agonists. We conclude that reduced adiponectin expression under high-fat dietary conditions is dependent on 1) increased ALDH1A1 expression in adipocytes, which does not increase all-trans-retinoic acid levels; 2) further RAR ligand-induced, WAT-selective, increased retinoic acid response element-mediated signaling; and 3) RAR ligand-dependent reduction of adiponectin expression.-Landrier, J.-F., Kasiri, E., Karkeni, E., Mihály, J., Béke, G., Weiss, K., Lucas, R., Aydemir, G., Salles, J., Walrand, S., de Lera, A. R., Rühl, R. Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.

KEYWORDS:

diabetes; nuclear hormone receptor; obesity; retinaldehyde dehydrogenase; vitamin A

PMID:
27729412
PMCID:
PMC5161515
DOI:
10.1096/fj.201600263RR
[Indexed for MEDLINE]
Free PMC Article

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