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Int J Parasitol. 2016 Dec;46(13-14):829-832. doi: 10.1016/j.ijpara.2016.08.004. Epub 2016 Oct 10.

Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Author information

1
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA; Departamento de Clínica Médica, Laboratório de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Immunopathogesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
2
Liver Regeneration and Repair Research Group, Institute of Hepatology, Foundation for Liver Research, London, UK; Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC, USA; Section of Gastroenterology, Ralph H Johnson Veteran Affairs Medical Center, Charleston, SC, USA.
3
Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
4
Departamento de Clínica Médica, Laboratório de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
5
Centers for Disease Control and Prevention, Atlanta, GA, USA.
6
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address: diehl004@mc.duke.edu.

Abstract

Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.

KEYWORDS:

Biomarker; Liver fibrosis; Osteopontin; Portal hypertension; Schistosomiasis mansoni

PMID:
27729270
PMCID:
PMC5584370
DOI:
10.1016/j.ijpara.2016.08.004
[Indexed for MEDLINE]
Free PMC Article

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