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Curr Biol. 2016 Oct 10;26(19):R895-R898. doi: 10.1016/j.cub.2016.08.031. Epub 2016 Oct 10.

Gene Regulation: Activation through Space.

Author information

1
Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.
2
Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, 1030 Vienna, Austria. Electronic address: stark@starklab.org.

Abstract

A recent study visualizes nascent RNAs in live Drosophila embryos to establish a connection between enhancer strength and the frequency of transcriptional bursts. Interestingly, one enhancer can simultaneously activate two core promoters, challenging models of enhancer-core-promoter communication via direct protein-protein contacts.

PMID:
27728794
DOI:
10.1016/j.cub.2016.08.031
[Indexed for MEDLINE]
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