Format

Send to

Choose Destination
Clin Transplant. 2016 Dec;30(12):1578-1583. doi: 10.1111/ctr.12860.

Thyroid hormone use during cardiac transplant organ procurement.

Author information

1
Inova Heart & Vascular Institute, Falls Church, VA, USA.
2
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
3
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
4
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
5
Carolina Donor Services, Durham, NC, USA.
6
Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.

Abstract

BACKGROUND:

Acute hypothyroidism after brain death results in hemodynamic impairments that limit availability of donor hearts. Thyroid hormone infusions can halt that process and lead to increased utilization of donor organs, but prolonged use of thyroid replacement has not been well studied.

METHODS:

We developed a 15-question survey regarding policies, procedures, and reporting of thyroid hormone use by organ procurement organizations (OPOs). The survey was posted for 5 weeks on the Association of OPOs Portal.

RESULTS:

We received 29 responses, representing 24 OPOs. Seventy-two percent reported their OPOs use thyroid hormone for all potential donors and 90% have a protocol for thyroid hormone use. There is a large variation in the maximum dose of thyroid hormone used, and many OPOs have no weaning protocol. Most OPOs do not collect data on total thyroid hormone administered during procurement and would favor more detailed report of thyroid hormone use.

CONCLUSIONS:

Thyroid hormone use can have important implications for organ selection and cardiac function before and after transplantation. Protocols vary widely with respect to why and how to use and wean thyroid hormone. We believe there should be more detailed reporting of thyroid hormone use for future studies to ensure appropriate donor management.

KEYWORDS:

donor management; heart transplant; procurement; survey; thyroid hormone

PMID:
27726211
PMCID:
PMC5135659
DOI:
10.1111/ctr.12860
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center