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J Neuroimmunol. 2016 Oct 15;299:59-61. doi: 10.1016/j.jneuroim.2016.08.011. Epub 2016 Aug 12.

Immune-mediated rippling muscle disease and myasthenia gravis.

Author information

1
Neuromuscular Diseases Section, Neurology Department, Italian Hospital of Buenos Aires, Argentina. Electronic address: mariela.bettini@hospitalitaliano.org.ar.
2
Neuromuscular Diseases Section, Neurology Department, Italian Hospital of Buenos Aires, Argentina.
3
Neurology Department, Cesar Milstein Care Unit, Buenos Aires, Argentina.
4
Neurology Department, San Roque Hospital, La Plata, Argentina.
5
Unit of Neuromuscular and Neurodegenerative Disorder, Bambino Gesu' Children's Hospital, Rome, Italy.

Abstract

Cases of acquired rippling muscle disease in association with myasthenia gravis have been reported. We present three patients with iRMD (immune-mediated rippling muscle disease) and AChR-antibody positive myasthenia gravis. None of them had thymus pathology. They presented exercise-induced muscle rippling combined with generalized myasthenia gravis. One of them had muscle biopsy showing a myopathic pattern and a patchy immunostaining with caveolin antibodies. They were successfully treated steroids and azathioprine. The immune nature of this association is supported by the response to immunotherapies and the positivity of AChR-antibodies.

KEYWORDS:

AchR antibodies; Autoimmune; Caveolin; Myasthenia; Rippling

PMID:
27725122
DOI:
10.1016/j.jneuroim.2016.08.011
[Indexed for MEDLINE]

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