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Nat Chem Biol. 2016 Dec;12(12):998-1000. doi: 10.1038/nchembio.2180. Epub 2016 Oct 10.

Serine is a new target residue for endogenous ADP-ribosylation on histones.

Author information

1
Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, Cologne 50931, Germany.
2
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
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Contributed equally

Abstract

ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.

PMID:
27723750
PMCID:
PMC5113755
DOI:
10.1038/nchembio.2180
[Indexed for MEDLINE]
Free PMC Article

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