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Nat Neurosci. 2016 Dec;19(12):1665-1671. doi: 10.1038/nn.4405. Epub 2016 Oct 10.

Unstable neurons underlie a stable learned behavior.

Author information

1
Department of Biology, Boston University, Boston, Massachusetts, USA.
2
Graduate Program in Neuroscience, Boston University, Boston, Massachusetts, USA.
3
Center for Regenerative Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
4
The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
5
Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
6
Program in Neuroscience, Harvard University, Cambridge, Massachusetts, USA.
7
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
8
Brain Institute, Federal University of Rio Grande de Norte, Natal, Brazil.

Abstract

Motor skills can be maintained for decades, but the biological basis of this memory persistence remains largely unknown. The zebra finch, for example, sings a highly stereotyped song that is stable for years, but it is not known whether the precise neural patterns underlying song are stable or shift from day to day. Here we demonstrate that the population of projection neurons coding for song in the premotor nucleus, HVC, change from day to day. The most dramatic shifts occur over intervals of sleep. In contrast to the transient participation of excitatory neurons, ensemble measurements dominated by inhibition persist unchanged even after damage to downstream motor nerves. These observations offer a principle of motor stability: spatiotemporal patterns of inhibition can maintain a stable scaffold for motor dynamics while the population of principal neurons that directly drive behavior shift from one day to the next.

PMID:
27723744
PMCID:
PMC5127780
DOI:
10.1038/nn.4405
[Indexed for MEDLINE]
Free PMC Article

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