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Pediatr Obes. 2018 Jan;13(1):46-53. doi: 10.1111/ijpo.12187. Epub 2016 Oct 9.

The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn.

Author information

1
Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Australia.
2
Child Health Research Unit, Barwon Health, Geelong, Australia.
3
Department of Paediatrics, University of Melbourne, Parkville, Australia.
4
Deakin University, Geelong, Australia.
5
Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, Australia.
6
Department of Paediatrics, Monash University, Clayton, Australia.

Abstract

BACKGROUND:

Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth.

OBJECTIVES:

The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation.

METHODS:

Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n = 1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n = 161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis.

RESULTS:

Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8 g per kg m-2 , 95% CI 6.6 to 28.9; p = 0.002), newborn mean skin-fold thickness (mean difference 0.1 mm per kg m-2 , 95% CI 0.0 to 0.1; p < 0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kg m-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p = 0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP.

CONCLUSION:

Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.

KEYWORDS:

Neonatal; obesity; offspring; pregnancy

PMID:
27723247
DOI:
10.1111/ijpo.12187
[Indexed for MEDLINE]

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