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Neuropsychol Rehabil. 2018 Oct;28(7):1110-1130. doi: 10.1080/09602011.2016.1240697. Epub 2016 Oct 9.

Benefits from an autobiographical memory facilitation programme in relapsing-remitting multiple sclerosis patients: a clinical and neuroimaging study.

Author information

1
a Cognitive Neuropsychology and Physiopathology of Schizophrenia (INSERM UMR 1114) , University of Strasbourg , Strasbourg , France.
2
b ICube (CNRS UMR 7357) , University of Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS) , Strasbourg , France.
3
c Department of Neurology and Centre Mémoire de Ressources et de Recherche (CMRR) , University Hospital of Strasbourg , Strasbourg , France.
4
d Clinical Investigation Centre (CIC, INSERM 1434) , University Hospital of Strasbourg , Strasbourg , France.

Abstract

While the efficacy of mental visual imagery (MVI) to alleviate autobiographical memory (AM) impairment in multiple sclerosis (MS) patients has been documented, nothing is known about the brain changes sustaining that improvement. To explore this issue, 20 relapsing-remitting MS patients showing AM impairment were randomly assigned to two groups, experimental (n = 10), who underwent the MVI programme, and control (n = 10), who followed a sham verbal programme. Besides the stringent AM assessment, the patients underwent structural and functional MRI sessions, consisting in retrieving personal memories, within a pre-/post-facilitation study design. Only the experimental group showed a significant AM improvement in post-facilitation, accompanied by changes in brain activation (medial and lateral frontal regions), functional connectivity (posterior brain regions), and grey matter volume (parahippocampal gyrus). Minor activations and functional connectivity changes were observed in the control group. The MVI programme improved AM in MS patients leading to functional and structural changes reflecting (1) an increase reliance on brain regions sustaining a self-referential process; (2) a decrease of those reflecting an effortful research process; and (3) better use of neural resources in brain regions sustaining MVI. Functional changes reported in the control group likely reflected ineffective attempts to use the sham strategy in AM.

KEYWORDS:

Autobiographical memory; cognitive rehabilitation; functional neuroimaging; multiple sclerosis; voxel-based morphometry

PMID:
27718890
DOI:
10.1080/09602011.2016.1240697
[Indexed for MEDLINE]
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