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Mol Cell Pediatr. 2016 Dec;3(1):34. Epub 2016 Oct 7.

Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling.

Author information

1
Comprehensive Pneumology Center, Helmholtz Center Munich, Ludwig-Maximilians-University, University Hospital Grosshadern, German Center of Lung Research (DZL), Munich, Germany. chiharu.ota@helmholtz-muenchen.de.
2
Comprehensive Pneumology Center, Helmholtz Center Munich, Ludwig-Maximilians-University, University Hospital Grosshadern, German Center of Lung Research (DZL), Munich, Germany.
3
The Perinatal Center, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.

KEYWORDS:

Adult chronic lung diseases; Bronchopulmonary dysplasia (BPD); Lung development; WNT signaling

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