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BMC Cancer. 2016 Oct 7;16(1):774.

With or without reirradiation in advanced local recurrent nasopharyngeal carcinoma: a case-control study.

Liu LT1,2, Chen QY1,2, Tang LQ1,2, Zhang L1,2, Guo SS1,2, Guo L1,2, Mo HY1,2, Zhao C1,2, Guo X1,2, Chen MY1,2, Qian CN1,2, Zeng MS1, Hong MH1,3, Shao JY1,4, Sun Y1,5, Ma J1,5, Mai HQ6,7.

Author information

1
State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
2
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.
3
Good Clinial Practice Center, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
4
Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
5
Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
6
State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. maihq@sysucc.org.cn.
7
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China. maihq@sysucc.org.cn.

Abstract

BACKGROUND:

The study aimed to evaluate the long-term outcome in patients with advanced local recurrent nasopharyngeal carcinoma (NPC) treated with or without reirradiation.

METHODS:

A total of 44 patients treated without reirradiation (non-RT + chemotherapy) were matched with 44 patients treated with reirradiation (re-RT+/-chemtherapy) by age, sex, Karnosky performance score (KPS), rT stage, rN stage, and time interval between initial radiation and recurrence (TI). Overall survival (OS) rate and time to progression (TTP) rate were assessed using Kaplan-Meier method, log-rank test, and Cox regression analysis.

RESULTS:

From March 2008 to December 2013, a total of 88 well-balanced rT3-4 N0-1 NPC patients were retrospectively analyzed. After a median follow-up of 27 months (range: 6-85), the 5-year OS rate and TTP rate was 23.4 %, 39.0 % in the non-RT + chemotherapy group and 27.5 %, 49.8 % in the re-RT+/-chemtherapy group, respectively. Multivariate analysis showed that significant toxic effect was the only significant prognosticator correlated with OS (HR: 2.15, 95 % CI = 1.02-4.53, p = 0.044). No statistically significant survival differences were observed between the two treatment groups in either univariate or multivariate analyses.

CONCLUSION:

Compared with reiradiation, treating advanced local recurrent NPC with chemotherapy alone warrants further validation in the view of its similar survival and more acceptable toxicities.

KEYWORDS:

Chemotherapy; Recurrent nasopharyngeal carcinoma; Reirradiation

PMID:
27717335
PMCID:
PMC5054630
DOI:
10.1186/s12885-016-2803-2
[Indexed for MEDLINE]
Free PMC Article

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