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Oral Dis. 2017 Oct;23(7):828-839. doi: 10.1111/odi.12589. Epub 2016 Nov 24.

The autoimmunity-oral microbiome connection.

Author information

1
Department of Oral Pathology and Medicine, Dental School, University of Athens, Athens, Greece.
2
Dental School, University of Athens, Athens, Greece.
3
Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Abstract

To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the oral microbiome in autoimmune diseases. In this review article, we discuss links of the oral microbiota to a group of autoimmune diseases, that is, Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), Crohn's disease (CD), and rheumatoid arthritis (RA). We particularly focus on factors that affect the balance between the immune system and the composition of microbiota leading to dysbiosis, loss of tolerance and subsequent autoimmune disease progression and maintenance.

KEYWORDS:

Sjögren's syndrome; autoimmunity; crohn's disease; lupus erythematosus; oral microbiome; rheumatoid arthritis

PMID:
27717092
DOI:
10.1111/odi.12589
[Indexed for MEDLINE]

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