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Rev Gastroenterol Peru. 2016 Jul-Sep;36(3):219-224.

[Gastroprotective effect of honey in Holtzman rats with piroxicam-induced gastric ulcer].

[Article in Spanish]

Author information

1
Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
2
Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Scientia Clinical and Epidemiological Research Institute. Trujillo, Perú.
3
Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Círculo de Extensión Socio Cultural Daniel Alcides Carrión. Trujillo, Perú.
4
Facultad de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú; Sociedad Científica de Estudiantes de Medicina, Universidad Nacional de Trujillo. Trujillo, Perú.
5
Departamento de Ciencias Básicas, Medicina, Universidad Nacional de Trujillo. Trujillo,Perú.

Abstract

OBJECTIVE:

To determine the effect of treatment with honey in piroxicam-induced gastric ulcer in Holtzman rats.

MATERIALS AND METHODS:

48 eight-week old female Holtzman rats, weights between 100 and 200 grams, were divided into 6 treatment groups as follow: Group A: water; Group B: piroxicam (30 mg/kg); Group C: omeprazole (5 mg/kg) and piroxicam (30 mg/kg); Group D: honey (2.5 g/kg) and piroxicam (30 mg/kg); Group E: honey (5 g/kg) and piroxicam (30 mg/kg); Group F: honey (7.5 g/kg) and piroxicam (30 mg/kg). Macroscopic studies, using Scion Image, and microscopic histological section of gastric mucosa were performed after the interventions.

RESULTS:

The results of the macroscopic studies showed statistically significant differences for both doses of honey at 6 g/kg and 7.5 g/kg when compared to piroxicam (p=0.016 and p=0.001 respectively) and the gastroprotective effect was similar when compared to omeprazole (p>0.05). Microscopic studies showed statistically significant differences only for dose at 7.5 g/kg when compared to piroxicam (p=0.0018) and the gastroprotective effect was similar to omeprazole (p=1).

CONCLUSION:

Dose of honey at 7.5 g/kg showed gastroprotective effect at microscopic and macroscopic studies when compared to omeprazole.

PMID:
27716758
[Indexed for MEDLINE]

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